A tale of three taxes: photo-gyro-gravitactic bioconvection

The term bioconvection encapsulates the intricate patterns in concentration, due to hydrodynamic instabilities, that may arise in suspensions of non-neutrally buoyant, biased swimming microorganisms. The directional bias may be due to light (phototaxis), gravity (gravitaxis), a combination of viscous and gravitational torques (gyrotaxis) or other taxes. The aim of this study is to quantify experimentally the wavelength of the initial pattern to form from an initially well-mixed suspension of unicellular, swimming green algae as a function of concentration and illumination. As this is the first such study, it is necessary to develop a robust and meticulous methodology to achieve this end. The phototactic, gyrotactic and gravitactic alga Chlamydomonas augustae was employed, with various red or white light intensities from above or below, as the three not altogether separable taxes were probed. Whilst bioconvection was found to be unresponsive to changes in red light, intriguing trends were found for pattern wavelength as a function of white light intensity, depending critically on the orientation of the illumination. These trends are explored to help unravel the mechanisms. Furthermore, comparisons are made with theoretical predictions of initial wavelengths from a recent model of photo-gyrotaxis, encouragingly revealing good qualitative agreement

Populist Nationalism Threatens Health and Human Rights in the COVID-19 Response

COVID-19 demands international cooperation, yet populist nationalism is resurgent, threatening public health, human rights, and global governance. In responding to the pandemic, populist nationalism and global solidarity represent distinct paths, with enduring consequences for health and human rights. (Am J Public Health. Published online ahead of print October 29, 2020: e1–e3. https://doi.org/10.2105/AJPH.2020.305952

Geology of Exeter and its environs

A 225 km² area around Exeter, described in this report, extends from the villages of Brampford Speke and Whimple in the north to Aylesbeare, Exminster and Woodbury in the south. It is underlain by Carboniferous, Permian, and Triassic solid formations and by a variety of Quaternary superficial deposits. The Namurian Crackington Formation comprises mainly tightly folded shales with subordinate sandstone interbeds. The Permian rocks consist of a lower, predominantly: breccia, sequence (Whipton Formation, Teignmouth Breccia, Monkerton Member) that thins and disappears northwards against a possibly fault-controlled ridge of Crackington Formation; the breccias are overlain by sandstones and mudstones (Dawlish Sandstone and Aylesbeare Mudstone). Volcanic rocks occur at the base of the Permian sequence and possibly within the Dawlish Sandstone. The latter splits into five alternating sandstone and mudstone members when traced northwards from Exeter into the Crediton Trough (an area of thick Permian sediments). The Aylesbeare Mudstone is divisible south of Aylesbeare into two members, the lower containing impersistent sandstones. It is overlain by the basal Triassic gravels (Budleigh Salterton Pebble Beds) which are in turn succeeded by the Otter Sandstone

Translating Patient-Oriented Eczema Measure (POEM) scores into clinical practice by suggesting severity strata derived using anchor-based methods

Background: The Patient-Oriented Eczema Measure (POEM) is a validated, patient-derived assessment measure for monitoring atopic eczema severity, although further information on how different POEM scores translate into disease severity categories is needed for clinical trials, epidemiological research and audit. Objectives: We sought to determine the relationship between Patient-Oriented Eczema Measure (POEM) scores (range 0–28) and two Global Questions (GQ1 and 2) concerning patients’/parents’ views of the overall severity of their/their child’s atopic eczema, in order to stratify POEM scores into five severity bands. Methods: POEM scores and GQs were completed by 300 patients from general practice and 700 patients from dermatology outpatient clinics, including 300 adults aged ≥ 16 years and 700 children. Results: The mean POEM score was 136 (range 0–28), and standard deviation (SD) was 72. Mean GQ1/GQ2 scores were 21/21, respectively (range 0–4 and SD 11 for both). The mean, mode and median of the GQ scores for each POEM score were used to devise possible POEM bandings. The proposed banding for POEM scores are: 0–2 (clear/almost clear); 3–7 (mild); 8–16 (moderate); 17–24 (severe); 25–28 (very severe), kappa coefficient 046. Conclusions: Severity banding of the POEM will allow more clinically meaningful use in everyday clinical practice and as a core outcome measure in future atopic eczema research

Ending the abuse: the human rights implications of obstetric violence and the promise of rights-based policy to realise respectful maternity care

In September 2019, Dubravka Šimonovic, the United Nations (UN) Special Rapporteur on violence against women (VAW), submitted her report to the UN General Assembly on “mistreatment and VAW during reproductive health services with a focus on childbirth and obstetric violence”. This report solidified obstetric violence as a form of VAW – a human rights violation to be addressed by the UN, rather than solely a matter of quality of care for maternal health professionals. The positioning opens new channels for interdisciplinary advocacy to be translated into multisectoral policy. However, the risk is that rights-based approaches remain siloed within the human rights community, rather than serving as a foundation for broadbased policy reforms

Automated, high accuracy classification of Parkinsonian disorders: a pattern recognition approach

Progressive supranuclear palsy (PSP), multiple system atrophy (MSA) and idiopathic Parkinson’s disease (IPD) can be clinically indistinguishable, especially in the early stages, despite distinct patterns of molecular pathology. Structural neuroimaging holds promise for providing objective biomarkers for discriminating these diseases at the single subject level but all studies to date have reported incomplete separation of disease groups. In this study, we employed multi-class pattern recognition to assess the value of anatomical patterns derived from a widely available structural neuroimaging sequence for automated classification of these disorders. To achieve this, 17 patients with PSP, 14 with IPD and 19 with MSA were scanned using structural MRI along with 19 healthy controls (HCs). An advanced probabilistic pattern recognition approach was employed to evaluate the diagnostic value of several pre-defined anatomical patterns for discriminating the disorders, including: (i) a subcortical motor network; (ii) each of its component regions and (iii) the whole brain. All disease groups could be discriminated simultaneously with high accuracy using the subcortical motor network. The region providing the most accurate predictions overall was the midbrain/brainstem, which discriminated all disease groups from one another and from HCs. The subcortical network also produced more accurate predictions than the whole brain and all of its constituent regions. PSP was accurately predicted from the midbrain/brainstem, cerebellum and all basal ganglia compartments; MSA from the midbrain/brainstem and cerebellum and IPD from the midbrain/brainstem only. This study demonstrates that automated analysis of structural MRI can accurately predict diagnosis in individual patients with Parkinsonian disorders, and identifies distinct patterns of regional atrophy particularly useful for this process

Spatial variation in the effects of size and age on reproductive dynamics of common coral trout Plectropomus leopardus

The effects of size and age on reproductive dynamics of common coral trout Plectropomus leopardus populations were compared between coral reefs open or closed (no-take marine reserves) to fishing and among four geographic regions of the Great Barrier Reef (GBR), Australia. The specific reproductive metrics investigated were the sex ratio, the proportion of vitellogenic females and the spawning fraction of local populations. Sex ratios became increasingly male biased with length and age, as expected for a protogyne, but were more male biased in southern regions of the GBR (Mackay and Storm Cay) than in northern regions (Lizard Island and Townsville) across all lengths and ages. The proportion of vitellogenic females also increased with length and age. Female P. leopardus were capable of daily spawning during the spawning season, but on average spawned every 4·3 days. Mature females spawned most frequently on Townsville reserve reefs (every 2·3 days) and Lizard Island fished reefs (every 3·2 days). Females on Mackay reefs open to fishing showed no evidence of spawning over 4 years of sampling, while females on reserve reefs spawned only once every 2–3 months. No effect of length on spawning frequency was detected. Spawning frequency increased with age on Lizard Island fished reefs, declined with age on Storm Cay fished reefs, and declined with age on reserve reefs in all regions. It is hypothesized that the variation in P. leopardus sex ratios and spawning frequency among GBR regions is primarily driven by water temperature, while no-take management zones influence spawning frequency depending on the region in which the reserve is located. Male bias and lack of spawning activity on southern GBR, where densities of adult P. leopardus are highest, suggest that recruits may be supplied from central or northern GBR. Significant regional variation in reproductive traits suggests that a regional approach to management of P. leopardus is appropriate and highlights the need for considering spatial variation in reproduction where reserves are used as fishery or conservation management tools

Wearable device to assist independent living.

Older people increasingly want to remain living independently in their own homes. The aim of the ENABLE project is to develop a wearable device that can be used both within and outside of the home to support older people in their daily lives and which can monitor their health status, detect potential problems, provide activity reminders and offer communication and alarm services. In order to determine the specifications and functionality required for development of the device user surveys and focus groups were undertaken and use case analysis and scenario modeling carried out. The project has resulted in the development of a wrist worn device and mobile phone combination that can support and assist older and vulnerable wearers with a range of activities and services both inside and outside of their homes. The device is currently undergoing pilot trials in five European countries. The aim of this paper is to describe the ENABLE device, its features and services, and the infrastructure within which it operates

Geology of Sheet SZ 19 (Hurn-Christchurch): part of 1:50 000 sheet 329 (Bournemouth)

The original geological survey of the area comprising sheet SZ 19 was made by H W Bristow and J Trimmer at the one-inch to one-mile scale (1:63 360) as parts of Old Sheets 15 and 16 published in 1856 and 1855 Series Geological respectively. The drift deposits were not represented on these maps. Clement Reid resurveyed the area on the six-inch to one-mile scale (1:10,560) in 1893, and his results were incorporated in New Series One-Inch Geological Sheet 329 (Bournemouth), published in 1895 in both Solid and Drift editions, and in the accompanying memoir (Reid, 1898). A second edition of this memoir was produced by H J 0 White, and was published in 1917. White re-examined much of the ground, but the published maps remained unaltered. In 1983 the Institute of Geological Sciences (now British Geological Survey) was commissioned by the Department of the Environment (contract PECD7/1/0103-149/82) to provide new 1:10,000 geological maps of the Poole-Bournemouth area. This contract comprises the survey of ten 1:10,000 sheets, and parts of four others, (Figure 1) over three years, to form a basis for the planning of urban and industrial development, and the safeguarding of mineral and water resources. During 1983, in the first phase of the contract, the four constituent quadrants of Sheet SZ 19 were mapped as follows, under the direction of R W Gallois, District Geologist: SZ 19 NW B J Williams; SZ 19 NE E C Freshney; SZ 19 SW E C Freshney; SZ 19 SE C R Bristow

Chronic infection of domestic cats with feline morbillivirus, United States

Letter [No abstract available